Lyme Disease rarely infects ones body without one or more of these Co-Infections, adding to the difficulty of successful treatment or eradication of the disease. Here is a good list of Co-Infections, that includes most, but probably not all Co-Infections.


Explanation: Protozoa (parasites) that invade, infect, and kill the red blood cells.
Symptoms: Fatigue, night sweats, fever, chills, weakness, weight loss, nausea, abdominal pain, diarrhea, cough, shortness of breath, headache, neck and back stiffness, dark urine or blood in urine
Treatment: Atovaquone (Mepron) plus Azithromycin (Zithromax), Clindamycin and oral Quinine
Other: Alternative treatment may include Riamet or Artemisinin


Explanation: Bartonella bacterium.
Symptoms: Fever, chills, headache and severe pain in the tibia, weight loss, sore throat, papular or angiomatous rash
Treatment: Erythromycin, plus a Fluoroquinolone or Rifampin

 Ehrlichiosis (HGE and HME):

Explanation: Rickettsiae that infect the white blood cells.
Symptoms: Anemia, fever, chills, headache, muscle pain, rigors, gastrointestinal symptoms, anorexia, fatigue
Treatment: Doxycycline, Rifampin

 Rocky Mountain spotted fever:

Explanation: Rickettsia rickettsii parasite that invades the cells lining the heart and blood vessels.
Symptoms: High fever, severe headache (especially behind the eyes), maculopapular skin rash
Treatment: Tetracycline, Doxycycline, or Chloramphenicol

 Colorado Tick Fever:

Explanation: Reovirus that lodges inside the cells.
Symptoms: High fever, chills, severe muscle aches, back pain, headache (especially behind the eyes), light sensitivities, nausea, vomiting, diarrhea
Treatment: No antiviral therapy is available
Other: Aspirin

Relapsing Fever:

Explanation: Borrelia hermsii spirochete.
Symptoms: High fever, sudden chills, eye inflammation, coughing, jaundice, petechial rash
Treatment: Tetracycline, Doxycycline, or Chloramphenicol


Explanation: Francisella tularensis bacterium.
Symptoms: Painful and swollen lymph nodes, fever, chills, fatigue
Treatment: Tetracycline, Chloramphenicol

Powassan Encephalitis:

Explanation: Flavivirus that invades and infects the brain.
Symptoms: Fever, headache, pain behind the eyes, light sensitivity, muscle weakness, seizures, paralysis, brain inflammation
Treatment: No effective treatment

Tick Paralysis:                                                            Explanation: A toxic reaction to saliva from female ticks. Symptoms: Paralysis begins in legs and spreads throughout the body within hours                                                     Treatment: Recovery is rapid following the removal of the tick

Mycoplasma:                                                                     Explanation: A genus of small bacteria which lack cell walls. Symptoms: Fatigue, headaches, muscle pain and soreness, nausea, gastrointestinal problems, joint pain and soreness, lymph node pain, cognitive problems, depression, breathing problems and other signs and symptoms                                                                                             Treatment: Slow-growing mycoplasmal infections are not rapidly susceptible to antibiotics. Doxycycline, Minocycline, Ciprofloxacin, Azithromycin, and Clarithromycin may be used.

Chlamydia Pneumoniae:                                                                                      Explanation: (Cpn) is a tiny bacterium which is most often noted for causing a form of pneumonia.                                                        Symptoms:  In the respiratory tract, Chlamydia pneumoniae causes atypical pneumonia, including a non-productive but persistent cough, headache, and generally not feeling well. The bug may also cause infections such as bronchitis, laryngitis, pharyngitis, rhinitis, and sinusitis. Many people who have it experience no symptoms or only mild symptoms, which explains the “walking pneumonia” name. If fever is present, it usually occurs early in the infection. Unlike most other pneumonia-causing pathogens, C. pneumoniae can cause a fairly severe sinusitis.                                                                                 Treatment:  Doxycycline, Tetracycline, Erythromycin, Azithromycin, Clarithromycin or the newer drug Telithromycin.

Ehrlichiosis:                                                                                                                              Explanation: refers to several tick-borne diseases caused by very small organisms called Ehrlichiae, which affect both humans and animals. Ehrlichiae are gram negative bacteria that infect and destroy white blood cells.                                                                               Symptoms:   The clinical manifestations of ehrlichiosis and anaplasmosis are the same. Each is often characterized by sudden high fever, fatigue, muscle aches, headache. The disease can be mild or life-threatening.  Severely ill patients can have low white blood cell count, low platelet count, anemia, elevated liver enzymes, kidney failure and respiratory insufficiency. Older people or people with immune suppression are more likely to require hospitalization. Deaths have occurred.                                                                                                                                              Treatment:  The treatment of choice for ehrlichiosis/anaplasmosis is doxycycline, with rifampin recommended in case of treatment failure.

3 Responses to Co-Infections

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  2. We are trying to get more information into Australia as well about all the forms and symptoms of Lyme Disease. According to the government in Australia it “does not exist”, so there is no treatment covered. Makes it a little hard to get everything we need for treatment. I will be linking your site if that’s ok…I have a lot of ways that I am trying to get the money together to pay for it all as it’s not funded. I am not sure on the rules everywhere else, hopefully it’s not as bad as here…
    Great Content…
    David Cant

    • Hi David, for the longest time, Lyme did not exist here either. More and more people are speaking out about it and it’s getting too hard to hide. I hope this will be the case for you and all of the people in Australia dealing with such a difficult disease. Lyme is one day at a time or sometimes, one hour at a time. Try to stay positive, do what you can and leave the rest up to God, who loves and cares for us. I hope you find the right treatment for you. If you are not taking antibiotics, eat lot’s of garlic, drink real lemon in your water, take good supplements, try to sweat, eat healthy, get quality sleep, or basically be good to yourself! You deserve every bit of it!


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